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Natural American Spirit cigarettes typically contain more tobacco filler, resulting in more puffs per cigarette and increased exposure to tobacco chemicals

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According to PMI, millions of smokers around the world have switched completely from cigarette smoking to IQOS

[50] [51] [52] In 2011 there were about 7 million adult e-cigarette users globally, increasing to 68 million in 2020 compared with 1 } : CS1 maint: multiple names: authors list (link) "Nicotine vaping in England: an evidence update including health risks and perceptions, September 2022