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The fact that one reader was not blinded to smoking status may have introduced a possible bias, but it was shown that excellent inter-rater agreement was achieved with the blinded reader

Progressive commercial cigarette yield reduction: biochemical exposure and behavioral assessment

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Maternal smoking is clearly linked to abnormal hypothalamic gene expression of appetite regulators, with NPY and POMC gene expression in the arcuate nucleus of the hypothalamus being significantly downregulated in the newborn primate following intrauterine nicotine exposure (Grove et al., 2001)