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First, the self-medication hypothesis proposes that individuals with SZ choose to smoke to alleviate the clinical symptoms and cognitive deficits that are characteristic of the illness as well as the side effects of antipsychotic medications ( Neurobiological Determinants of Tobacco Smoking in Schizophrenia Nicotine Nicotine, the addictive component in tobacco cigarettes, binds to nicotinic acetylcholine receptors (nAChRs), which are endogenously expressed in the human brain and influenced by the native agonist, acetylcholine (4951)