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One method, the International Organization of Standardization (ISO) method, had the machine taking puffs that were two seconds long, every sixty seconds, with none of the filter vents in the machine blocked off

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2021 Jul 19 [cited 2023 Dec 1];12(1):605

This is based merely on their high risk factors, such as blood cholesterol or obesity, or genetics, the data proved that even in this elderly patient population, the benefits of aggressive antihypertensive drug treatment far outweighed the risks of the drugs side effectsand certainly outweighed the risks of doing no drug intervention at all in this population: at this point, lifestyle interventions like diet and exercise would not be sufficient according to the SPRINT Trial