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In February, Califf was using an e-cigarette when it exploded near his face, blasting a large hole in his cheek

In addition, traditional tobacco cigarettes are associated with the production of ROS and with vascular endothelial dysfunction, both of which can affect the integrity of the BBB [101]

A clinical trial of these RTPs, using a short-term (6-week) switching design, evaluated smoke toxicant exposure by measurement of various biomarkers of exposure (BoEs) among current smokers both before and after they switched from conventional cigarettes to the reduced toxicant prototype (RTP

Those revelations, and others that followed, helped lead to government inquiries, lawsuits, and promises of a global treaty to crack down on the illicit cigarette trade