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Villanti AC, Giovino GA, Barker DC, Mowery PD, Sevilimedu V, Abrams DB

Indeed, the use of extreme conditions increases the likelihood of eliciting a response, potentially allowing for small effects to be observed that would otherwise be missed or represented as no result and also allowing comparisons to combustible cigarettes via EC 50 values

In effect, this means that even light smoking in otherwise young healthy people can damage the arteries, compromising the ability of their bodies to cope with physical stress, such as climbing a set of stairs or running to catch a bus, says Dr