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Response: We thank the commenters for their feedback and will take these recommendations into consideration as we further examine the logic for case assignment

Structurally, secreted peptide signals can be categorized into two primary groups: post-translationally modified peptides (PTM) and cysteine-rich peptides (CRP) ( PTM peptides are secreted only after undergoing modification and processing within the secretory pathway, and with common modifications including tyrosine sulfation, proline hydroxylation, and hydroxyproline arabinosylation (Tavormina et al., 2015

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