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These include: Canker sores that become unusually large Recurring sores New sores that occur before old ones heal Frequent sore outbreaks Canker sores that are persistent, lasting two or more weeks You experience pain thats not ameliorated with self-care measures Drinking or eating is extremely difficulty High fever that accompanies canker sores Canker sores that extend to the lips Furthermore, most canker sores will get better over time and heal without any medication within two to three weeks