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Toxicokinetics Nicotine, a weak base alkaloid (pKa = 8.5), is poorly absorbed from the stomach because it is ionised in the acidic gastric fluid, but is well absorbed in the small intestine, which has an alkaline pH and a large surface area 10 , 11

As for the 6th weeks stage of the study, groups B, C and D presented edematous changes with hemorrhagic signs, cellular necrosis with vacuolations, cellular infiltrates and distortions in parenchymal tissue architecture Fig