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The dysregulation of the immune system by smoking can also contribute to autoimmune diseases, and it creates conflicting regulatory effects on T regulatory cells, potentially predisposing individuals to infections [25]

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For example, a 2018 review by Public Health England estimated that tobacco-free nicotine products like nicotine pouches are likely at least 95% less harmful than smoked tobacco products, highlighting the significantly reduced health risks in comparison to traditional tobacco-based products (Public Health England, 2018)