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Nicotine is rapidly metabolized by liver cytochrome P450s into cotinine and distributed across the cerebrovascular system (Fukada et al., 2002a)

TRICARE, the health care program for members of the military, military retirees and their dependents, covers prescription and over-the-counter quitting medications at no cost to military personnel

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IQOS use rates increased 10-fold among young adults in Japan between 2016 and 2017, credited to PMI introducing the product on a well-known television program