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"Formaldehyde-releasing agents may deposit more efficiently in the respiratory tract than gaseous formaldehyde, and so they could carry a higher slope factor for cancer." Peter Hajek, director of the Tobacco Dependence Research Unit at Barts and The London School of Medicine and Dentistry, said the study did not reflect real-world conditions

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It was also shown in dogs that CS can decrease the active ion transport and therefore the electrical potential difference across the tracheal epithelium, altering the respiratory tract fluidity and consequently affecting the mucociliary clearance 27