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HDL levels over 116 mg/dL for men or 135 mg/dL for women cause an increase in the risk of heart disease.[ref] HDL cholesterol also plays a role in the immune system, with higher levels of HDL associated with better outcomes from parasites and bacterial infections.[ref] Genetics and HDL: HDL cholesterol levels are considered to be about half due to genes (with the rest due to diet, infection, etc.).[ref][ref] CETP gene: The CETP gene codes for the cholesteryl ester transfer protein, which moves triglycerides or cholesterol between VLDL or LDL and HDL particles