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Varenicline and bupropion are prescription medicines licensed in the UK for smoking cessation

Otherwise, they would have applied for that designation, using the same mechanism/criteria that apply to the patch, lozenges and gum

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According to the Food and Drug Administration (FDA), a product can contain as little as 50% synthetic nicotine and still be labeled as synthetic. Manufacturers say the tobacco-derived nicotine used in their products is purified or synthetic, but purifying nicotine derived from tobacco enough to reach medicinal levels is expensive