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The erlotinib and metformin combination also enhanced AMPK-dependent phosphorylation of acetyl-coA carboxylase (ACC), a major downstream effector of AMPK in lipid metabolism, and attenuated mTOR-mediated 4EBP1 phosphorylation and Ki67 cell proliferation marker in the tumor tissues (Fig

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Funding: Cancer Research UK Tobacco Advisory Group (CRUK C51836/A25751) provided financial support for the study