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This was partly due to a national effort, and in fact, the legal age is now 21 in all 50 states

In the context of the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guideline 36 , it is crucial to recognize that reliance on self-reported data may impact the external validity of our findings

The use of NRT is supported by a well-established and favorable safety profile, even when used beyond the recommended 12-week period, and they effectively help smokers quit 28 , with better efficacy when combining two NRT products (patch as long-acting and one short-acting product) 29

Archive of our previous thread for newcomers or those looking to brush up: com/qstarchive/2026/6359994/ It isn't especially long, easy to review, and I think sets the stage well