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Droughts are not uncommon and, despite the fact that historical evidence suggests they have always been a problem in the region, many blame irresponsible loggers in the more northerly countries on the Mekong for exacerbating the situation

To further confirm this chain of causal inference, we implemented a modified Mendelian randomisation (MR) analysis to investigate potential causal effects by introducing non-pleiotropic polygenic risk scores (PRS) as instrument variables, i.e., the valid-PRS (see Methods for more details) 35,36

Additionally, these are available in 3mg, 6mg, and 12mg nicotine bases, as well as a nicotine-free version for those who prefer the juicy taste by itself

Thinner cigars are usually more potent and burn quicker, while longer, thicker cigars are mild and burn slowly