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There was high certainty that quit rates were higher in people randomized to nicotine e-cigarettes than in those randomized to nicotine replacement therapy (risk ratio [RR]1.63, 95% confidence interval [CI] 1.30 to 2.04) and moderate-certainty evidence, limited by imprecision, that quit rates were higher in people randomized to nicotine e-cigarettes than to e-cigarettes without nicotine (RR 1.94, 95% CI 1.21 to 3.13)

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The agency also needs to know whether there were any other symptoms, details about preceding events such as duration and intensity of e-cigarette use, and details about the resulting health effects