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Medications to ask your healthcare provider about in terms of possible interactions with fluconazole include: Blood thinners Statins (cholesterol-lowering medications) Certain immunosuppressants Corticosteroids Fluoroquinolone Antipsychotic medications Macrolide antibiotics Narcotic pain relievers Heart medication for irregular heartbeats Typically, a one-time dose will not cause a drug-drug interaction, says Dr

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