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First, CCA was used to identify the strongest components of gene correlation structure that were shared across donors (using Seurats RunMultiCCA function) based on the union of the top 10,000 most informative genes involving two or more of the three donors (9542 genes total)

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2000 Carcinogenesis 21 : 107111 Acknowledgements The work of the authors was supported by grants from the National Institutes of Health (CA84469 to GP Pfeifer