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the other dog was euthanised due to financial constraints rather than clinical deterioration

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The NADPH oxidase (Nox) system is a major source of intracellular ROS production in the adult brain and the nicotine withdrawal induced activation of the Nox isoform-Nox-2 expression in microglia, which is believed to be the primary mechanism that results in increased ROS generation and pro-inflammatory response to nicotine withdrawal (131, 132)

An appropriate explanation of why and how the social gradient emerges and persists therefore leads us to examine the processes surrounding individual smoking behaviour