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Betel quid users have reported experiencing withdrawal symptoms that are similar to nicotine withdrawal, 11 including: cravings feelings of distress/discomfort dry mouth irritability anxiety fatigue inability to concentrate altered taste

The couple had one son, Thomas Rolfe, born in 1615

Assessment of biomarkers of exposure and potential harm, and physiological and subjective health measures in exclusive users of nicotine pouches and current, former and never smokers