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Naik Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia Firzan Nainu College of Health Sciences, Cihan University Sulaimaniya, Sulaimaniya, Iraq Hastyar Hama Rashid Najmuldeen University of Sulaimani, Sulaymaniyah, Iraq Hastyar Hama Rashid Najmuldeen Department of Health and Rehabilitation Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia Gopal Nambi Suraj Eye Institute, Nagpur, India Vinay Nangia School of Pharmacy, University of Reading, Reading, UK Atta Abbas Naqvi Mysore Medical College and Research Institute, Government Medical College, Mysore, India Sreenivas Narasimha Swamy School of Dentistry, University of Utah, Salt Lake City, UT, USA Gustavo G

The data is clear: Nicotine activates POMC neurons, reducing hunger (Mineur et al., 2011) Nicotine raises energy expenditure ~10% (Hofstetter et al., 1986) Quitting nicotine causes ~4.67 kg weight gain at 12 months (Aubin et al., 2012) 80% of quitters gain weight (Aveyard et al., 2012) NRT delays but doesn't prevent post-quit weight gain (Farley et al., 2012) Vaping doesn't "make you lose weight." Nicotine does modestly, temporarily, and at a cost that includes physical dependence, cardiovascular stress, and inevitable weight rebound when you stop

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