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In addition, youll have elevated levels of the following: Glucose levels: Nicotine triggers adrenaline, which then increases your blood sugar White blood cell count: Smoking activates the immune system Carboxyhemoglobin: This happens from inhaled carbon monoxide Long-Term Effects of Smoking on Blood Tests Not only can smoking have immediate and temporary changes to your blood chemistry, organ function, and disease markers, but chronic smoking can also lead to persistent alterations