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But then it depends on the country

utilizing family members, significant others, caregivers, and/or friends to help resolve the crisis

Unlike clotting factors, which promptly restore balance in the coagulation cascade at the point of deficiency or bridge activated Factor IX and Factor X to restore the function of missing activated Factor VIII, [294] allowing for stable blood clot formation and hemostasis, the gene therapies do not directly integrate into the coagulation cascade