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An examination of adolescents ranging in age from 12 to 19 found that heritability estimates for initiation of smoking ranged from 36% to 56% across varying samples, with similar heritability estimates for regular smoking ranging from 27% to 52%

In anticipation of these issues, in 1999 the FDA asked the Institute of Medicine (IOM) to convene a committee of experts to formulate scientific methods and standards by which PREPs (pharmaceutical or tobacco related) could be assessed

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