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Apart from the recognised factors that affect substance use disorders in general, examination of the particular association between smoking and schizophrenia raises three main possible hypotheses: first, patients smoke at an increased frequency because smoking ameliorates some of the symptoms of schizophrenia and side-effects of medication second, smoking causes an increased predisposition to develop psychosis third, common genetic risk factors make some individuals more vulnerable to developing schizophrenia and nicotine dependence