The National Institute on Drug Abuse notes that frequent cannabis use can lead to cannabis use disorder, which includes tolerance, dependence, and withdrawal when you stop
Dual Users vs Cigarette-Only Smokers Compared with all cigarette-only smokers, all dual users had significantly higher concentrations of most biomarkers, including most major nicotine metabolites, 3 TSNAs (including NNAL), 2 metals, 5 PAHs (including the biomarker for pyrene), and 13 VOCs (including biomarkers for acrolein and acrylonitrile)
aluminum, brass, and the metal bodies of some e-cigarette devices)
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