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Confirmed fibromyalgia was present only in 1 patient with the most severe form of cEDS, carrying a structural mutation in COL5A2 (Patient 14 in Additional Table 1), who also suffered from recurrent muscle hematomas and ruptures

Intervention programmes carried out in schools and under clinical environment have invariably developed and delivered effective results in contrast to therapy and treatment under strict pharmacological surveillance

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Dr Penny Woods, chief executive of the British Lung Foundation, said:Children are particularly susceptible to the dangers of the toxic fumes released by smoking due to their smaller lungs, faster breathing and less-developed immune systems