These situations can include an inability to establish a rapport with a patient because of pervasive psychiatric symptoms, a lack of time, development of refractory or potentially fatal side effects that might require discontinuation of clozapine, a subtherapeutic response to clozapine, and the need for augmentation strategies, rechallenge, polypharmacy (especially when more than 1 antipsychotic medication is used), and comorbidity of other psychiatric disorders (eg, substance use disorders)
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The differentiator is that instead of a rules-based mandate that identifies stocks using certain criteria and a particular weighting strategy, Vanguard uses screens to narrow down the potential universe of stocks before selecting the final components and weighting them according to a proprietary methodology
