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3 Metabolic drivers of macrophage dysfunction in COPD The increase in both total and polarized AMs may drive COPD pathogenesis through multiple mechanisms, including the secretion of proinflammatory cytokines, chemokines, and MMPs, along with impaired phagocytic and bactericidal functions (75)

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Temporal sequencing of nicotine dependence and bipolar disorder in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)

Story highlights We've known smoking can kill you for at least 50 years, yet millions still smoke The number of people who smoke has been on the decline, but that number has plateaued Smoking behaviors rewire your brain to want the nicotine and the smoking behaviors Smoking can kill you