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The flare indicates a histamine reaction from white blood cells in the skin that cause itching and swelling due to an accumulation of immune fluid

If supported by other work, the studys findings may mean that pod-based electronic cigarettes offer an even greater risk of nicotine dependence than other nicotine [and] tobacco products in this vulnerable population, says psychologist Thomas Eissenberg of Virginia Commonwealth University in Richmond, who coauthored a commentary accompanying the study

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