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A small amount of ROS oxidizes and damages intracellular proteins and activated transcription factors as second messengers in cell signaling pathways, a process which is essential for cell survival, reproduction, and adaptation to stimuli (Juan et al., 2021)

While they did not rate flavored cigarettes as less harmful than other brands, it is worth noting that smoothness and mild taste may be indirectly associated with a perception of reduced harm 35 , which may have influenced respondents perceptions of harmfulness at the smoking initiation stage

Lancet Public Health 7 , E834E843 (2022)

E-cigarette teeth discoloration from nicotine, aerosol deposits, and vaping-induced dry mouth is real, documented, and progressive, and many patients who switch to vaping are surprised to find their teeth continuing to yellow