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Funding for the study was provided by National Institutes of Health grants P30 ES000260, R01 HL139239, and T32 ES007324

Abstract To assess how tobacco smoking status affects baseline dopamine D2/D3 (D2R) receptor availability and methylphenidate-induced dopamine (DA) release, we retrospectively analyzed D2R availability measures of 8 current smokers, 10 ex-smokers, and 18 nonsmokers who were scanned with positron emission tomography and [ 11 C]raclopride, after administration of an injection of placebo or 0.5 mg/kg i.v

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