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American Heritage defines it as "an inactive substance or preparation used as a control in an experiment or test to determine the effectiveness of a medicinal drug." Merriam-Webster defines it as "an inert or innocuous substance used especially in controlled experiments testing the efficacy of another substance." Is nicotine an inactive, inert, and innocuous substance

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The FDA recently estimated that the number of middle and high school students using e-cigarettes in 2024 is about 1.63 million, down from 2.13 million in 2023, with the vast majority using flavored nicotine