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The strongest design would follow an entire population of youth beginning at an age at which risk of use of any product is negligible (e.g., 10 years old) and investigate time-varying associations between e-cigarette ever use and later combustible tobacco cigarette use at multiple developmental stages throughout the entire period of risk (e.g., up until age 29), while using multiple methods to establish temporal precedence of vaping relative to smoking

Ethics statements Patient consent for publication Acknowledgments I would like to thank Emily Mullins, MPH, for helpful assistance in the preparation of the final manuscript, and Michael Chaiton, PhD, for helpful comments on a draft manuscript

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