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Flavored e-cigarettes are the most popular form of tobacco product used by teenagers 85 percent.[10] As early as 2014, it was reported that e-cigarettes were the most commonly used tobacco product among adolescents in the United States.[11] In 2020, TW Wang et al published a report where 3.6 million middle and high school students reported current e-cigarettes use and more than 80% of current users reported flavored e-cigarette use.[12] The use of tobacco products by youth, including e-cigarettes, is unsafe

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One reason may be that the genetic variants change the effect of nicotine in the body

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