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Reference Thomson, Berk, Dodd, Rapado-Castro, Quirk and Ellegaard7Reference Slyepchenko, Brunoni, McIntyre, Quevedo and Carvalho9 First, nicotine binds to subtypes of the nicotinic acetylcholinergic receptor, which is implicated in the regulation of central nervous system pathways relevant to mood disorders

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Model coefficients are reported as adjusted odds ratios (AORs) with corresponding 95% confidence intervals (CIs), and the area under the receiver operating characteristic curve (ROC-AUC) was used to evaluate the models discriminatory ability in distinguishing between successful and unsuccessful smoking cessation cases

122 Amy Fairchild et al., Evidence, Alarm, and the Debate over Ecigarettes, Science 366, no