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When incubated with brain endothelial cells, cotinine and nicotine decrease ZO-1 expression ( Moreover, the comparative effect of TS and e-cig extract showed that downregulation of ZO-1 protein from e-cig was not dissimilar to that from TS extract treatment (Kaisar et al., 2017)

Among the small-scale contract farmers interviewed for this report, many reported that they did not receive copies of the contracts they signed with tobacco companies, leaving them vulnerable to risks if a company was to modify the terms of a contract unilaterally, or deny the existence of a contractual relationship

While THC vape pens are primarily designed for use with THC oil concentrates, some devices may be compatible with other cannabis concentrates, such as wax, shatter, or live resin