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Nicotine could contribute to this progression by aggravating vasoconstriction, although other tobacco smoke toxins are also likely to be contributing to progressive vascular injury. In laymans terms this tells us that nicotines impact as a vasoconstrictor (shrinking blood vessels which increases blood pressure) can contribute, alongside the other chemicals in cigarette smoke, to more severe conditions brought about by prolonged hypertension

However, the nicotine doesnt just jump from the pouch to the membrane of the gums, a vehicle is required

Participants were randomly assigned to use either a 5% nicotine e-cigarette or an identical device with zero nicotine 52 per group

"There's no loophole to close," King said, pointing to FDA's recent actions against disposable makers