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Acknowledgements We acknowledge Dr Martin Figeac from the Functional and Structural Platform (CHU Lille, France) for transcriptomic analyses and Dr OLivier Molendi-Coste and Hlne Bauderlique from the Bicell platform (Universit de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41UAR 2014PLBS, 59000 Lille, France) for the flow cytometry analysis