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Science 177 , 619621 (1972)

Keeping such disabilities at bay right now can be much stronger motivation to continue using nicotine than any threats of diseases that may strike Nicotines beneficial effects can be controlled, and the detrimental effects of the smoky delivery system can be attenuated, by providing the drug via less hazardous delivery systems

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When flavored vapes like Juul took off among teens, Mitch Zeller was the Director of the FDAs Center for Tobacco Products, and sympathetic to the harm reduction philosophy