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But some of the flavor additives used in products like Juul are known lung irritants, said David Ashley, a professor of public health at Georgia State University and former director of the Office of Science in the FDAs Center for Tobacco Products

Plasma samples were spiked with 0.05% aqueous formic acid containing a deuterated internal standard of cotinine, extracted with a solid phase resin, and analyzed using LC-MS/MS via multiple reaction monitoring (MRM) to quantitate cotinine