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For models with significant bias covariates selected in the primary analysis, we examined the impact of running the models without providing any bias covariates for potential inclusion in the model with and without 10% trimming

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Age: Pediatric Patients CHANTIX is not recommended for use in pediatric patients 16 years of age or younger because its efficacy in this population was not demonstrated [see Use in Specific Populations (8.4)]

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