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In 2025, the program engaged 1.2 million participants, achieving a 6-month abstinence rate of 18%, up from 14% in 2022

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the extract was subsequently filtered to remove a proportion of polyphenols and proteins, and insoluble tobacco proteins were removed by treatment with protease

Its forms vary between acute (sudden onset), recurrent (four or more infections per year), and treatment-resistant (when symptoms persist for a long time or are difficult to treat)