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When experiencing ischemiareperfusion injury, exposure to nephrotoxic or pneumotoxic agents (such as cisplatin or cigarette smoke, CS), or systemic inflammatory and infectious stress, mitochondrial dysfunction leads to excessive reactive oxygen species (ROS) production, bioenergetic failure, and activation of cell death pathways ( Mitophagy is regulated by a coordinated network that includes the canonical PINK1/Parkin pathway and stress-responsive regulators, such as hypoxia-inducible factor-1 (HIF-1) ( Clinically, kidney and lung dysfunction frequently occur together rather than in isolation

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