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4 Simply being exposed to a marijuana trigger like a pipe or rolling papers can increase activity in the following brain regions or structures: 4 Ventral tegmental area - Houses some of the brains reward circuitry and is involved with motivation and reinforcement of certain behaviors Thalamus - Relay point for numerous sensory pathways Amygdala - Involved with emotional processing and the formation of associations between certain cues or triggers and drug use behavior Other imaging studies have suggested that long-term marijuana use may also affect regions of the brain involved with memory, such as the hippocampus