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The animal toxicology results were based on a small number of rats in each experiment, raising the possibility that the failure to detect statistically significant changes in the end points was due to underpowering the experiments rather than lack of a real effect

You dont have to be rude, but its important to make it clear that youre not interested in smoking

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The 14-year age statement is itself significant within the Method and Madness range, where most expressions carry no age statement