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The influential National Academy of Sciences report concluded that using an e-cigarette indoors may involuntarily expose non-users to nicotine and particulates but also that the effects of such exposure remain unknown

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The study demonstrated good emissions study practices by thoroughly documenting the ENDS test specimen product characteristics, TPM yield per puff, Y TPM , TPM mass concentration, C TPM , and descriptive statistics of the nominal coil resistance, R coil , and nicotine mass ratio, f Nic , expressed as mg of nicotine per mg of TPM

Some countries have outright bans on importation or use, with severe penalties