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Age at cigarette-use initiation, sex, income, alcohol consumption, and motivation to quit smoking were used as time-independent confounders

Vaccination is done at this age in an attempt to provide immunity in adolescents that are about to become sexually active

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Some researchers have observed that CS can induce the deposition of proteases, thereby driving the accumulation of ubiquitinated proteins (aggregates) in epithelial cells and exacerbating chronic inflammation (van Rijt et al., 2012)